Longitudinal effects of Johnson & Johnson COVID-19 vaccination on metabolic biomarkers in type 2 diabetes mellitus in Ethiopia

Table 7 Generalized estimating equations multiple regression analysis for prostaglandin

Variables (n = 224)		Crude effect		Adjusted effect
		β (95%CI)	P value	β (95%CI)	P value
Vaccination status	Vaccinated	-0.03 (-0.62, 0.57)	0.9331	-0.04 (-0.56, 0.48)	0.880
	Unvaccinated	Reference		Reference
Age group	≤ 40 years	-0.53 (-1.07, 0.01)	0.055a	-0.68 (-1.20, -0.17)	0.010b
	> 40 years	Reference		Reference
Sex	Female	0.83 (0.32, 1.33)	0.001a	0.45 (-0.11, 1.01)	0.118
	Male	Reference		Reference
Alcohol exposure	Yes	-0.53 (-1.17, 0.10)	0.101a	-0.33 (-0.94, 0.27)	0.281
	No	Reference		Reference
Chat exposure	Yes	0.31 (-0.42, 1.04)	0.407
	No	Reference
Smoking exposure	Yes	0.58 (-1.07, 2.24)	0.488
	No	Reference
Medications			0.001a		< 0.001b
	Insulin	-0.33 (-1.01, 0.34)	0.335	-0.37 (-1.03, 0.29)	0.278
	Metformin	-1.12 (-1.71, -0.53)	< 0.001	-1.22 (-1.79, -0.65)	< 0.001b
	Both	Reference
Intercept				26.51

^aP ≤ 0.20.

^bP < 0.05

¹Biological criteria.

95%CI: 95% confidence interval.