Longitudinal effects of Johnson & Johnson COVID-19 vaccination on metabolic biomarkers in type 2 diabetes mellitus in Ethiopia

Table 2 Longitudinal changes in lipid and eicosanoid biomarkers in the vaccinated and unvaccinated groups

Outcomes	Baseline		3 months		6 months		9 months		1 year
	MD	ES	MD	ES	MD	ES	MD	ES	MD	ES
TG	-0.57 (-7.46, 6.32)	-0.00	3.29 (-0.37, 6.96)	0.14	1.33 (-2.31, 4.97)	0.06	-1.34 (-5.09, 2.41)	-0.10	-2.34 (-6.09, 1.41)	-0.10
P value	0.869		0.078		0.471		0.482		0.220
HDL	1.42 (-0.90, 3.74)	0.18	-4.33 (-5.57, -3.09)	-0.60	-2.62 (-3.78, -1.45)	-0.40	2.09 (0.89, 3.30)	0.27	2.38 (1.22, 3.55)	0.33
P value	0.229		< 0.001a		< 0.001a		0.001a		< 0.001a
TC	1.42 (-4.04, 6.87)	0.06	-16.44 (-20.36, -12.51)	-0.70	-0.39 (-3.98, 3.19)	-0.00	-0.20 (-3.33, 2.93)	-0.00	2.74 (-0.86, 6.33)	0.12
P value	0.609		0.001a		0.829		0.898		0.135
PG	-0.03 (-0.63, 0.58)	-0.00	-0.03 (-0.63, 0.58)	-0.00	-0.03 (-0.63, 0.58)	-0.00	-0.03 (-0.63, 0.58)	-0.00	-0.03 (-0.63, 0.58)	-0.00
P value	0.933		0.933		0.933		0.933		0.933
TX	-0.09 (-0.17, 0.00)	-0.30	-0.09 (-0.18, -0.01)	-0.30	-0.08 (-0.15, 0.01)	-0.30	-0.09 (-0.18, -0.01)	-0.30	-0.08 (-0.15, 0.01)	-0.30
P value	0.041a		0.038a		0.036a		0.038a		0.036a

^aP < 0.05.

Values are represented as the mean difference (95% confidence interval of mean difference range). ES: Effect size HDL: High-density lipoprotein; MD: Mean difference; PG: Prostaglandin; TC: Total cholesterol; TG: Triglyceride; TX: Thromboxane.