Associations of nontraditional lipoprotein ratios with future cardiovascular events in patients with type 2 diabetes mellitus

Table 3 Threshold effect analyses of nontraditional lipoprotein ratios on major adverse cardiovascular events

Characteristics	One linear-regression model	Inflection point (K)	< K, effect 1	> K, effect 2	P value for LRT
TC/HDL-C	1.09 (1.06-1.13), P < 0.0001	7.29	1.14 (1.09-1.19), P < 0.0001	0.97 (0.88-1.07), P = 0.4915	0.003
LDL-C/HDL-C	1.16 (1.10-1.21), P < 0.0001	1.35	0.64 (0.30-1.36), P = 0.2453	0.97 (0.88-1.08), P = 0.5786	0.140
Non-HDL-C/HDL-C	1.09 (1.06-1.13), P < 0.0001	6.29	1.14 (1.09-1.19), P < 0.0001	0.97 (0.88-1.07), P = 0.4915	0.003
RC/HDL-C	1.08 (1.03-1.14), P = 0.0014	2.15	1.24 (1.13-1.36), P < 0.0001	0.95 (0.86-1.05), P = 0.3543	< 0.001

The effects shown are adjusted for Model 4, including sex, age, race, educational level, depression, cigarette-smoking status, duration of type 2 diabetes mellitus, previous cardiovascular events, previous heart failure, previous hypertension, body mass index, systolic blood pressure, diastolic blood pressure, hemoglobin A1c, fasting blood glucose, estimated glomerular filtration rate, insulin use, biguanide use, beta-blocker use, and statin use. TC: Total cholesterol; HDL-C: High-density lipoprotein cholesterol; LDL-C: Low-density lipoprotein cholesterol; RC: Remnant cholesterol; LRT: Likelihood ratio test.