Effect of ranibizumab on diabetic retinopathy via the vascular endothelial growth factor/STAT3/glial fibrillary acidic protein pathway

Figure 10  Expression of glial fibrillary acidic protein, signal transducer and activator of transcription 3 (STAT3), and phosphorylated STAT3 proteins in the retinal tissues of each group of Sprague-Dawley rats. A: Detection of glial fibrillary acidic protein (GFAP), signal transducer and activator of transcription 3 (STAT3), and phosphorylated STAT3 (pSTAT3) protein expression in the retinal tissues of Sprague-Dawley (SD) rats using Western blot analysis; B: Ratio of GFAP protein expression in the retinal tissues of each group of SD rats; C: Ratio of STAT3 protein expression in the retinal tissues of each group of SD rats; D: Ratio of pSTAT3 protein expression in the retinal tissues of each group of rats. All results are expressed as the mean ± SD. ^aP < 0.05. ^bP < 0.01. ¹P vs A group. ²P vs C group. ³P vs D group. ⁴P vs F group. GAPDH: Glyceraldehyde-3-phosphate dehydrogenase.