Systemic immune indicators for predicting renal damage in newly diagnosed type 1 diabetic children

Figure 3 Predictors of systemic inflammatory indices in newly diagnosed type 1 diabetes mellitus children. A: Linear regression analysis and parameter covariance (heat map) of systemic immune inflammation index levels, showing urinary albumin-to-creatinine ratio (UACR) as the strongest predictor with a significant positive association (estimate = 1.955, P < 0.0001); B: Linear regression analysis and parameter covariance (heat map) of neutrophil-to-lymphocyte ratio levels, highlighting the significant positive contribution of diastolic blood pressure (estimate = 0.056, P = 0.019) and UACR (estimate = 0.005, P < 0.001); C: Linear regression analysis and parameter covariance (heat map) of platelet-to-lymphocyte ratio levels, demonstrating the strong baseline relationship with platelet-to-lymphocyte ratio and significant associations with triglycerides and UACR. SII: Systemic immune inflammation index; TG: Triglycerides; HbA1c: Glycated hemoglobin; DBP: Diastolic blood pressure; UACR: Urinary albumin-to-creatinine ratio; TC: Total cholesterol; NLR: Neutrophil-to-lymphocyte ratio; PLR: Platelet-to-lymphocyte ratio.