Shenzhuo formulation ameliorates diabetic nephropathy by regulating cytochrome P450-mediated arachidonic acid metabolism

Figure 5 Shenzhuo formulation intervention in diabetic nephropathy mice suppresses inflammatory response and oxidative stress. A-C: Shenzhuo formulation (SZF) intervention significantly down-regulated the levels of IL-1β (A), IL-6 (B), and TNF-α (C) in renal tissues of diabetic nephropathy (DN) mice, and also attenuated the inflammatory response in DN mice; D-F: SZF intervention significantly up-regulated SOD activity (D) and GSH-Px activity (E), and also down-regulated MDA levels (F). This improved antioxidant capacities and attenuated oxidative stress levels in DN mice. n = 10 per group. ^bP < 0.01 vs control group; ^cP < 0.05; ^dP < 0.01 vs model group; IL-1β: Interleukin-1β; IL-6: Interleukin-6; TNF-α: Tumor necrosis factor-α; SOD: Superoxide dismutase; GSH-Px: Glutathione peroxidase; MDA: Malondialdehyde; SZFM: Shenzhuo formulation medium dose group; SZFH: Shenzhuo formulation high dose group; SZFL: Shenzhuo formulation low dose group; Control: Control group; PC: Positive control group; Model: Model group.