Comparisons of various insulin resistance indices for new-onset metabolic syndrome before midlife: The CHIEF cohort study, 2014-2020

Table 3 Receiver operating characteristic curve analysis of various non-insulin-based insulin resistance indices and related components for incidence of metabolic syndrome

	Model 1			Model 2
	AUC	95%CI	P value	AUC	95%CI	P value
METS-IR index	0.781	0.761-0.800	Reference	0.782	0.762-0.801	Reference
TyG index	0.734	0.713-0.755	0.001	0.734	0.713-0.756	0.001
ALT/AST	0.677	0.654-0.699	< 0.001	0.674	0.652-0.697	< 0.001
TC/HDL-C	0.732	0.711-0.753	0.001	0.731	0.709-0.752	< 0.001
TG/HDL-C	0.751	0.731-0.771	0.03	0.752	0.731-0.772	0.04
ZJU index	0.744	0.723-0.765	0.01	0.743	0.722-0.764	0.008
FPG	0.608	0.584-0.632	< 0.001	0.605	0.581-0.630	< 0.001
TG	0.721	0.700-0.743	< 0.001	0.723	0.701-0.744	< 0.001
BMI	0.771	0.752-0.790	0.47	0.771	0.752-0.790	0.43
TC	0.613	0.588-0.638	< 0.001	0.613	0.588-0.638	< 0.001
HDL-C	0.689	0.667-0.712	< 0.001	0.690	0.667-0.712	< 0.001
AST	0.632	0.607-0.656	< 0.001	0.632	0.608-0.656	< 0.001
ALT	0.693	0.671-0.715	< 0.001	0.692	0.670-0.714	< 0.001

Receiver operating characteristic curve analysis was used to determine the area under curve with adjustments for age, sex, alcohol consumption status, tobacco smoking status, and physical activity levels in model 1 and further adjustment for waist circumference in model 2. AUC: Area under curve; METS-IR: Metabolic score for insulin resistance; TyG: Triglyceride glucose; ALT: Alanine transaminase; AST: Aspartate transaminase; TC: Total cholesterol; HDL-C: High-density lipoprotein cholesterol; TG: Triglyceride; ZJU: Zhejiang University; FPG: Fasting plasma glucose; BMI: Body mass index.