Methylation status of leptin gene promoter in relatively lean Chinese adults with prediabetes and type 2 diabetes mellitus

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World Journal of Diabetes

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1948-9358

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World J Diabetes. Dec 15, 2025; 16(12): 112789
Published online Dec 15, 2025. doi: 10.4239/wjd.v16.i12.112789

Table 3 General clinical data and leptin protein expression, n (%)

	Impaired glucose regulation	Type 2 diabetes mellitus	Normal glucose tolerance
	Impaired fasting glucose, impaired glucose tolerance	Type 2 diabetes mellitus	Normal glucose tolerance
Number (male/female)	44 (20/24), 50 (26/24)	178 (88/90)	120 (60/60)
Age (years)	49.4 ± 6.2, 47.2 ± 6.3	47.5 ± 5.5	46.7 ± 7.4
Body mass index (kg/m²)	22.37 ± 2.66, 23.23 ± 3.52	22.99 ± 2.53	21.19 ± 3.42
Leptin (μg/L)	13.79 ± 3.32, 12.62 ± 4.81	16.94 ± 4.19^a	11.33 ± 3.10
Hypertension (%)	12 (27.3), 17 (34)	41 (23.1)	26 (21.7)
Smoking (%)	9 (20.5), 12 (26)	44 (24.7)	27 (22.5)

^aq = 6.81, P < 0.01 for leptin levels in type 2 diabetes mellitus group: vs normal glucose tolerance. Data presented as mean ± SD or percentage.

Citation: Sun SQ, Liang SZ, Huang Q, Sun JZ. Methylation status of leptin gene promoter in relatively lean Chinese adults with prediabetes and type 2 diabetes mellitus. World J Diabetes 2025; 16(12): 112789
URL: https://www.wjgnet.com/1948-9358/full/v16/i12/112789.htm
DOI: https://dx.doi.org/10.4239/wjd.v16.i12.112789

Sun SQ, Liang SZ, Huang Q, Sun JZ. Methylation status of leptin gene promoter in relatively lean Chinese adults with prediabetes and type 2 diabetes mellitus. World J Diabetes 2025; 16(12): 112789 [PMID: 41480608 DOI: 10.4239/wjd.v16.i12.112789]

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