Methylation status of leptin gene promoter in relatively lean Chinese adults with prediabetes and type 2 diabetes mellitus

Table 2 Number of cases with leptin gene promoter methylation

Clinical classification	Number of cases (n)	Leptin gene methylation	Methylation rate (%)
		Positive (complete/incomplete), negative
Type 2 diabetes mellitus	178	56 (21/35), 122	31.5a,b,c
Impaired glucose regulation	94	41 (16/25), 53	43.6d
Impaired fasting glucose	44	17 (7/10), 27	38.6e
Impaired glucose tolerance	50	24 (11/13), 26	48
Normal glucose tolerance	120	71 (32/39), 49	59.2

^aP = 0.000, χ² = 22.499: vs normal glucose tolerance.

^bP = 0.047, χ² = 3.962: vs impaired glucose regulation.

^cP = 0.030, χ² = 4.688: vs impaired glucose tolerance.

^dP = 0.024, χ² = 5.109: vs normal glucose tolerance.

^eP = 0.019, χ² = 5.457: vs normal glucose tolerance.