Effect of glucagon-like peptide-1 receptor agonists on gastric mucosal visibility during upper endoscopy in Asian patients with diabetes

doi:10.4239/wjd.v16.i12.112694

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Diabetes. Dec 15, 2025; 16(12): 112694
Published online Dec 15, 2025. doi: 10.4239/wjd.v16.i12.112694

Table 4 Multivariate analysis of risk factors for aborted esophagogastroduodenoscopy

Characteristic	Propensity matched patients (n = 493)
Characteristic	Unadjusted OR (95%CI)	P value	Adjusted OR (95%CI)	P value
GLP-1RA	10.738 (3.122-61.014)	0.0010	11.099 (3.172-63.760)	0.0010
Age	0.973 (0.932-1.019)	0.2313	-	-
Sex (male)	0.715 (0.272-1.959)	0.4988	-	-
BMI	1.142 (1.018-1.276)	0.0201	1.121 (0.994-1.259)	0.0555
HbA1c	1.118 (0.746-1.603)	0.5653	-	-
Insulin use	1.003 (0.322-2.726)	0.9951	-	-
DM complication	1.979 (0.749-5.338)	0.1656	-	-
Low eGFR	4.628 (1.377-13.324)	0.0068	4.137 (1.153-12.992)	0.0191
Hypertension	1.120 (0.426-3.121)	0.8204	-	-
Cardiovascular disease	3.066 (0.896-8.797)	0.0490	-	-
Cerebrovascular accident	1.660 (0.176-7.124)	0.5652	-	-
Gastric modulator
Increasing motility¹	1.095 (0.062-19.281)	0.9507	-	-
Decreasing motility²	2.249 (0.120-12.428)	0.4484	-	-

¹Gastric modulators increasing motility included prokinetic agents.

²Gastric modulators decreasing motility included tricyclic antidepressants, opioid medications, and anticholinergic agents.

OR: Odds ratio; CI: Confidence interval; GLP-1RA: Glucagon-like peptide-1 receptor agonist; BMI: Body mass index; DM: Diabetes mellitus; eGFR: Estimated glomerular filtration rate; HbA1c: Hemoglobin A1c.

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Citation: Oh YE, Kim TS, Chi SA, Park HJ, Min YW, Lee H, Lee JH, Rhee PL, Kim JJ, Min BH. Effect of glucagon-like peptide-1 receptor agonists on gastric mucosal visibility during upper endoscopy in Asian patients with diabetes. World J Diabetes 2025; 16(12): 112694
URL: https://www.wjgnet.com/1948-9358/full/v16/i12/112694.htm
DOI: https://dx.doi.org/10.4239/wjd.v16.i12.112694

Oh YE, Kim TS, Chi SA, Park HJ, Min YW, Lee H, Lee JH, Rhee PL, Kim JJ, Min BH. Effect of glucagon-like peptide-1 receptor agonists on gastric mucosal visibility during upper endoscopy in Asian patients with diabetes. World J Diabetes 2025; 16(12): 112694 [PMID: 41480609 DOI: 10.4239/wjd.v16.i12.112694]

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