Identification of novel therapeutic targets for diabetic neuropathy through integrated proteomics and transcriptomics approaches

Figure 6 731 association of immune cells with diabetic neuropathy and mediation analysis. A: Forest plot of proteins with diabetic neuropathy (DN) Mendelian randomization analysis; B: Forest plot of immune cells vs DN Mendelian randomization analysis; C: Forest plot of identified proteins with Mendelian randomization analysis of positive immune cell; D: The effect of MICB on DN may be partially mediated by the human leukocyte antigen-DR (++) monocyte% leukocyte, with a mediating effect of 52.84%. DN: Diabetic neuropathy; WR: Wald ratio; nsnp: Number of single nucleotide polymorphisms; SNP: Single nucleotide polymorphisms; FDR: False discovery rate; HLA-DR: Human leukocyte antigen-DR; IVW: Inverse variance-weighted; OR: Odds ratio; CI: Confidence interval; Pval: P value.