Identification of novel therapeutic targets for diabetic neuropathy through integrated proteomics and transcriptomics approaches

Figure 4 Summary data-based Mendelian randomization plot of the MICB and BTN3A1 locus. The top panel depicts diabetic neuropathy genome-wide association studies P values (grey dots), the middle panel depicts expression quantitative trait loci P values, and the bottom panel depicts gene locations on chromosome 6. The red diamonds in the upper panel indicate the summary data-based Mendelian randomization test P values for positive genes, and the dashed lines indicate the significance thresholds. A: A locus plot of MICB; B: A locus plot of BTN3A1. eQTL: Expression quantitative trait loci; GWAS: Genome-wide association studies; SMR: Summary-data-based Mendelian randomization.