Identification of novel therapeutic targets for diabetic neuropathy through integrated proteomics and transcriptomics approaches

doi:10.4239/wjd.v16.i12.111963

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Evidence-Based Medicine

World J Diabetes. Dec 15, 2025; 16(12): 111963
Published online Dec 15, 2025. doi: 10.4239/wjd.v16.i12.111963

Table 5 Summary of key target protein integration results

Proteins (genes)	Direction for DN risk of protein	Direction for DN risk of gene	Passed SMR analysis	Passed coloc analysis
Tier 1
BTN3A1	(-)	(-)	Yes	Yes
MICB	(-)	(-)	Yes	Yes
Tier 2
PSMB9	(-)	(-)	No	Yes
HSPA1B	(-)	(-)	No	Yes
SCGN	(-)	X	X	Yes
Tier 3
CSNK2B	(+)	(+)	No	No
BRD2	(+)	(+)	No	No
WARS	(+)	X	X	No
NOTUM	(-)	X	X	No

(+) represents that the beta value is positive; (-) represents that the beta value is negative. X represents the loss in the analysis due to data issues, where the relevant gene was not found. “Yes” indicates that the analysis has passed, while “No” indicates that it has not passed. DN: Diabetic neuropathy; SMR: Summary-data-based MR.

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Citation: Ding XF, Dang X, Lin S. Identification of novel therapeutic targets for diabetic neuropathy through integrated proteomics and transcriptomics approaches. World J Diabetes 2025; 16(12): 111963
URL: https://www.wjgnet.com/1948-9358/full/v16/i12/111963.htm
DOI: https://dx.doi.org/10.4239/wjd.v16.i12.111963

Ding XF, Dang X, Lin S. Identification of novel therapeutic targets for diabetic neuropathy through integrated proteomics and transcriptomics approaches. World J Diabetes 2025; 16(12): 111963 [PMID: 41480606 DOI: 10.4239/wjd.v16.i12.111963]

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