Identification of novel therapeutic targets for diabetic neuropathy through integrated proteomics and transcriptomics approaches

doi:10.4239/wjd.v16.i12.111963

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Evidence-Based Medicine

World J Diabetes. Dec 15, 2025; 16(12): 111963
Published online Dec 15, 2025. doi: 10.4239/wjd.v16.i12.111963

Table 4 Mendelian randomization analysis of associations of plasma proteins with diabetic neuropathy in replicated stage (United Kingdom biobank pharma proteomics project vs genome-wide association studies catalog)

Outcome	Exposure	Method	nSNP	β	SE	P value
GCST90129436	HSPA1B	Inverse variance weighted	3	-	0.61	0.320
				0.60	0
				6	0
GCST90129436	SCGN	Wald ratio	1	1.322	0.627	0.035
GCST90129436	MICB	Inverse variance weighted	27	-0.132	0.062	0.035
GCST90129436	WARS	Inverse variance weighted	2	-0.211	0.215	0.326
GCST90129436	BRD2	(-)	-	-	-	-
GCST90129436	CSNK2B	(-)	-	-	-	-
GCST90129436	PSMB9	(-)	-	-	-	-
GCST90129436	BTN3A1	(-)	-	-	-	-
GCST90129436	NOTUM	(-)	-	-	-	-

(-) represents that there is no match in the dataset. nSNP: Number of SNP; SNP: Single nucleotide polymorphisms.

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Citation: Ding XF, Dang X, Lin S. Identification of novel therapeutic targets for diabetic neuropathy through integrated proteomics and transcriptomics approaches. World J Diabetes 2025; 16(12): 111963
URL: https://www.wjgnet.com/1948-9358/full/v16/i12/111963.htm
DOI: https://dx.doi.org/10.4239/wjd.v16.i12.111963

Ding XF, Dang X, Lin S. Identification of novel therapeutic targets for diabetic neuropathy through integrated proteomics and transcriptomics approaches. World J Diabetes 2025; 16(12): 111963 [PMID: 41480606 DOI: 10.4239/wjd.v16.i12.111963]

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