Identification of novel therapeutic targets for diabetic neuropathy through integrated proteomics and transcriptomics approaches

doi:10.4239/wjd.v16.i12.111963

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Evidence-Based Medicine

World J Diabetes. Dec 15, 2025; 16(12): 111963
Published online Dec 15, 2025. doi: 10.4239/wjd.v16.i12.111963

Table 3 Mendelian randomization analysis of associations of plasma proteins with diabetic neuropathy in replicated stage (United Kingdom biobank pharma proteomics project vs genome-wide association studies Finngen)

Outcome	Exposure	Method	nSNP	Beta	SE	P value
DN	HSPA1B	Inverse variance weighted	2	3.696	2.072	0.074
DN	SCGN	Wald ratio	1	-0.938	0.346	0.007
DN	MICB	Inverse variance weighted	29	-0.187	0.001	0.008
DN	WARS	Inverse variance weighted	3	0.482	0.168	0.004
DN	BRD2	(-)	-	-	-	-
DN	CSNK2B	(-)	-	-	-	-
DN	PSMB9	(-)	-	-	-	-
DN	BTN3A1	(-)	-	-	-	-
DN	NOTUM	(-)	-	-	-	-

(-) represents that there is no match in the dataset. nSNP: Number of single nucleotide polymorphisms; SNP: Single nucleotide polymorphisms; DN: Diabetic neuropathy.

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Citation: Ding XF, Dang X, Lin S. Identification of novel therapeutic targets for diabetic neuropathy through integrated proteomics and transcriptomics approaches. World J Diabetes 2025; 16(12): 111963
URL: https://www.wjgnet.com/1948-9358/full/v16/i12/111963.htm
DOI: https://dx.doi.org/10.4239/wjd.v16.i12.111963

Ding XF, Dang X, Lin S. Identification of novel therapeutic targets for diabetic neuropathy through integrated proteomics and transcriptomics approaches. World J Diabetes 2025; 16(12): 111963 [PMID: 41480606 DOI: 10.4239/wjd.v16.i12.111963]

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