Identification of novel therapeutic targets for diabetic neuropathy through integrated proteomics and transcriptomics approaches

Table 2 Mendelian randomization analysis of associations of plasma proteins with diabetic neuropathy in replicated stage (decode vs genome-wide association studies catalog)

Outcome	Exposure	Method	nSNP	Beta	SE	P value
GCST90129436	HSPA1B	Wald ratio	1	-0.997	1.117	0.372
GCST90129436	PSMB9	Wald ratio	1	1.346	1.542	0.383
GCST90129436	BTN3A1	Wald ratio	1	1.374	1.412	0.331
GCST90129436	SCGN	Inverse variance weighted	2	1.446	0.628	0.021
GCST90129436	NOTUM	Inverse variance weighted	4	-0.056	0.353	0.874
GCST90129436	MICB	Inverse variance weighted	22	-0.188	0.016	0.038
GCST90129436	WARS	Inverse variance weighted	6	-0.033	0.256	0.897
GCST90129436	BRD2	Wald ratio	1	3.393	1.267	0.007
GCST90129436	CSNK2B	Wald ratio	1	-5.066	1.980	0.010

nSNP: Number of single nucleotide polymorphisms; SNP: Single nucleotide polymorphisms.