Effect of fish scale ointment on diabetic foot ulcer by inducing ferroptosis via the nuclear factor E2-related factor 2 pathway

Table 4 Comparison of ferroptosis-related indexes in rat wound tissue

Group	Iron ion (μg/g)	MDA (mmol/g)	GSH (μmol/g)
Control (n = 5)	0.04 ± 0.01	3.10 ± 0.28	4.15 ± 0.36
Model (n = 5)	0.27 ± 0.01a	6.95 ± 0.31a	2.00 ± 0.08a
FSC (n = 5)	0.16 ± 0.02a,b	4.80 ± 0.22a,b	2.84 ± 0.22a,b
Control + Lip-1 (n = 5)	0.04 ± 0.02	2.99 ± 0.13	3.94 ± 0.09
Model + Lip-1 (n = 5)	0.20 ± 0.03a,b	5.08 ± 0.09a,b	2.66 ± 0.12a,b
FSC + Lip-1 (n = 5)	0.07 ± 0.02a,b,c	4.09 ± 0.07a,b,c	3.10 ± 0.14a,b,c
F	118.0	253.4	88.36
P value	< 0.0001	< 0.0001	< 0.0001

^aP < 0.05 vs control.

^bP < 0.05 vs model.

^cP < 0.05 vs fish scale collagen.

MDA: Malondialdehyde; GSH: Glutathione; FSC: Fish scale collagen; Lip-1: Liproxstatin-1.