Oral Akkermansia muciniphila may ameliorates immune dysregulation in a murine model of streptozotocin-induced type 1 diabetes

Figure 3 Comparison of zonulin and zonula occludens-1 expression in the colons of the mice in each group. A: Colonic zonula occludens-1 (ZO-1) expression histogram for the mice in each group (n = 10); B: Colonic zonulin expression histogram for the mice in each group (n = 10); C: Correlation analysis between ZO-1 and zonulin in the colon (n = 30). ^bP < 0.01 vs negative control group. ^cP < 0.001 vs negative control group. ^fP < 0.001 vs streptozotocin-induced type 1 diabetes mellitus group. NC group: Negative control group; STZ group: Streptozotocin-induced type 1 diabetes mellitus group; A. muciniphila group: Akkermansia muciniphila intervention group; ZO-1: Zonula occludens-1.