Oral Akkermansia muciniphila may ameliorates immune dysregulation in a murine model of streptozotocin-induced type 1 diabetes

Figure 1 Physiological and pathological changes in the mice in each group (400 times). A: Body weight line chart of the mice in each group (n = 10); B: Random blood glucose line chart for each group of mice (n = 10); C: Break-line diagram of the daily water intake of the mice in each group (n = 3); D: Hematoxylin-eosin staining changes in islet pathology in each group (400 times, n = 4); E: Changes in insulin immunohistochemical staining in each group (400 times, n = 6); F: Statistical analysis of the insulin-positive area ratio in each group (n = 6). 1-3 are three pairs of pathological hematoxylin-eosin changes from each group. ^aP < 0.05 vs negative control group. ^cP < 0.001 vs negative control group. NC group: Negative control group; STZ group: Streptozotocin-induced type 1 diabetes mellitus group; A. muciniphila group: Akkermansia muciniphila intervention group.