Impact of diabetes mellitus on mortality and atrial fibrillation in hypertrophic cardiomyopathy: A systematic review and meta-analysis

doi:10.4239/wjd.v16.i12.110494

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World Journal of Diabetes

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1948-9358

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Meta-Analysis

World J Diabetes. Dec 15, 2025; 16(12): 110494
Published online Dec 15, 2025. doi: 10.4239/wjd.v16.i12.110494

Table 1 Baseline characteristics of the included studies, mean ± SD/n (%)

Ref.	Study type	Country	Duration in years	Sample size	Age in years	Males	BMI in kg/m²	HTN	Dyslipidemia	Syncope	AF	DM	CAD	BB	CCB
Hajouli et al[13], 2024	R	United States	5	80502	63 ± 20	38954 (48.39)	30.6 ± 9.4	59241 (73.6)	NA	10384 (12.9)	14973 (18.6)	NA	22637 (28.1)	44944 (55.8)	NA
Wang et al[14], 2024	R	China	7	225	49.5 ± 13.6	119 (52.9)	25.7 ± 4.3	82 (36.4)	43 (19.1)	22 (9.7)	35 (15.5)	NA	NA	149 (66.2)	14 (6.2)
Lin et al[15], 2023	R	China	15	98	58.7 ± 16.5	82 (83.7)	26.3 ± 5.5	39 (39.7)	28 (28.5)	NA	NA	24 (24.5)	20 (20.4)	NA	NA
Lee et al[16], 2022	R	Korea	6	9883	58.5 ± 13.1^a	7085 (71.7)^a	N/A	5493 (55.6)	4158 (42.1)	NA	1119 (11.3)	1327 (13.4)	264 (2.7)	NA	NA
Sridharan et al[17], 2022	P	United States	4	2269	54 ± 15	1392 (61)	30 ± 3.4	613 (27)	885 (39)	227 (10)	454 (20)	250 (11)	181 (8)	N/A	N/A
Cui et al[18], 2022	R	United States	21	3859	54.8 ± 3.4	2115 (54.8)	28.6 ± 2	1764 (45.7)^a	NA	NA	556 (14.4)	357 (9.2)^a	454 (11.7)^a	3054 (79.1)^a	1398 (36.2)^a
Hsu et al[19], 2020	R	Taiwan	7	598	66.3 ± 13.0	262 (43.8)	NA	347 (58)	132 (22.1)	NA	NA	145 (24.2)	276 (46.2)	196 (32.8)	197 (32.9)
Raphael et al[20], 2020	P	United Kingdom	10	348	62 ± 14^a	254 (73)	NA	125 (36)	821 (23)	NA	NA	39 (11)	47 (14)	188 (54)^a	54 (16)
Rozen et al[21], 2020	R	United States	13	1885	62 ± 3.7^a	832 (53.2)^a	NA	1036 (55.5)	NA	NA	NA	288 (15.3)	NA	NA	NA
Meghji et al[22], 2019	R	United States	55	2506	55.6 ± 3.9	1379 (55)	29.65 ± 2.1	1238 (49.4)^a	1539 (61.4)	471 (18.8)	486 (19.4)	231 (9.2)	NA	1997 (79.7)	953 (38)
Nguyen et al[23], 2019	R	United States	56	2913	60.4 ± 2.7	2913 (54.9)	29.6 ± 1.8	1454 (49.9)	1784 (61.2)	NA	NA	284 (9.7)	NA	NA	NA
Li et al[24], 2019	R	China	13	319	48.2 ± 14.3	120 (54)	N/A	47 (21)	N/A	N/A	N/A	3 (1.34)	N/A	N/A	N/A
Jensen et al[25], 2011	P	Denmark	2	279	59 ± 14	150 (54)	NA	123 (44)	NA	NA	NA	19 (7)	NA	NA	NA
Moon et al[26], 2011	P	Korea	6	454	61 ± 11	316 (70)^a	NA	232 (51)^a	NA	5 (1)	NA	69 (15)^a	NA	142 (31)	118 (26)

^aP < 0.05.

BMI: Body mass index; HTN: Hypertension; AF: Atrial fibrillation; DM: Diabetes mellitus; CAD: Coronary artery disease; BB: Beta blockers; CCB: Calcium channel blockers; R: Retrospective cohort study; P: Prospective cohort study; N/A: Not applicable; NA: Not available.

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Citation: Damarlapally N, Vempati R, Doshi KM, Singh M, Prajapati K, Modi D, Singh P, Desai R. Impact of diabetes mellitus on mortality and atrial fibrillation in hypertrophic cardiomyopathy: A systematic review and meta-analysis. World J Diabetes 2025; 16(12): 110494
URL: https://www.wjgnet.com/1948-9358/full/v16/i12/110494.htm
DOI: https://dx.doi.org/10.4239/wjd.v16.i12.110494

Damarlapally N, Vempati R, Doshi KM, Singh M, Prajapati K, Modi D, Singh P, Desai R. Impact of diabetes mellitus on mortality and atrial fibrillation in hypertrophic cardiomyopathy: A systematic review and meta-analysis. World J Diabetes 2025; 16(12): 110494 [PMID: 41480615 DOI: 10.4239/wjd.v16.i12.110494]

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