Crosstalk between oxidative stress and inflammatory pathways: Natural therapeutic approaches for diabetic wound healing

Figure 3 Natural compounds and their mechanisms in promoting diabetic wound healing. T-AOC: Total antioxidant capacity; MCP-1: Monocyte chemoattractant protein-1; GCLC: Glutamate-cysteine ligase; 8-OHdG: 8-oxo-2'-deoxyguanosine; TRX: Thioredoxin; SIRT1/PGC-1α: Silent information regulator/Peroxisome proliferator-activated receptor-γ coactivator-1α; AMP-AMPK: Adenosine 5‘-monophosphate-activated protein kinase; G-CSF: Granulocyte colony-stimulating factor; M-CSF: Macrophage colony-stimulating factor; ECAR: Extracellular acidification rate; glycoPER: Glycolytic proton efflux rate; Rho/ROCK: Ras homolog gene/Rho-associated coiled-coil-forming protein kinase; STAT6: Signal transducer and activator of transcription 6; HOMA-IR: Homeostatic model assessment of insulin resistance; ASC: Apoptosis - associated speck - like protein containing a CARD; PPAR-γ: Peroxisome proliferator-activated receptor gamma; Bcl: B-cell lymphoma; TAS: Total antioxidant status; TOS: Total oxidant status; CXCL: C-X-C Motif chemokine ligand; IFN-γ: Interferon-γ; 8-iso-PG: 8-isoprostane; VCAM-1: Vascular cell adhesion molecule 1; COX2: Cyclooxygenase-2.