Crosstalk between oxidative stress and inflammatory pathways: Natural therapeutic approaches for diabetic wound healing

Figure 1 Crosstalk between oxidative stress and inflammatory signaling pathways. AGE: Advanced glycation end-products; ARE: Antioxidant response element; ERK: Extracellular signal-regulated kinase; HMGB1: High mobility group box 1; IRAK: Interleukin-1 receptor-associated kinase; JAK: Janus kinase; JNK: C-Jun N-terminal kinase; Keap1: Kelch-like ECH-associated protein 1; MAPK: Mitogen-activated protein kinase; MEK: Mitogen-activated extracellular signal-regulated kinase; NF-κB: Nuclear factor kappa-B; NEMO: NF-κB essential modulator; Nrf2: Nuclear factor erythroid 2-related factor 2;PI3K: Phosphoinositide 3-kinase; STAT3: Signal transducer and activator of transcription 3; TAB: TAK1-binding protein; TAK: Transforming growth factor-β activated kinase; TLR: Toll-like Receptor; TRAF6 TNF receptor-associated factor 6; Tyk2: Tyrosine kinase 2. Created in BioRender.