Association between circulating sex hormone levels and diabetic kidney disease in men and postmenopausal women with type 2 diabetes mellitus

doi:10.4239/wjd.v16.i11.111366

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Nov 15, 2025; 16(11): 111366
Published online Nov 15, 2025. doi: 10.4239/wjd.v16.i11.111366

Table 2 Correlation between sex hormones and renal function indexes in men with type 2 diabetes mellitus

r	BUN	Creatinine	eGFR	CysC	UACR	24-hour UARE
Testosterone	0.042	0.003	-0.078	0.11	-0.079	-0.092
DHEAS	-0.163^a	-0.113	0.387^a	-0.193^a	-0.11	-0.07
Androstenedione	-0.08	0.074	0.015	0.072	-0.042	-0.042
E2	-0.1	0.052	0.007	0.150^a	0.156^a	0.193^a
LH	0.199^a	0.248^a	-0.397^a	0.318^a	0.15^a	0.136^a
FSH	0.198^a	0.054	-0.307^a	0.131^a	0.009	-0.124

^aP < 0.05.

BUN: Blood urea nitrogen; CysC: Cystatin C; DHEAS: Dehydroepiandrosterone sulfate; E2: Levels of estradiol; eGFR: Estimated glomerular filtration rate; FSH: Follicle-stimulating hormone; LH: Luteinizing hormone; UACR: Urinary albumin/creatinine ratio; UARE: Urinary albumin excretion rate.

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Citation: Shi Y, Zhang Y, Zhou AD, Zou HY, Wang MM, Xu F, Cai MY. Association between circulating sex hormone levels and diabetic kidney disease in men and postmenopausal women with type 2 diabetes mellitus. World J Diabetes 2025; 16(11): 111366
URL: https://www.wjgnet.com/1948-9358/full/v16/i11/111366.htm
DOI: https://dx.doi.org/10.4239/wjd.v16.i11.111366

Shi Y, Zhang Y, Zhou AD, Zou HY, Wang MM, Xu F, Cai MY. Association between circulating sex hormone levels and diabetic kidney disease in men and postmenopausal women with type 2 diabetes mellitus. World J Diabetes 2025; 16(11): 111366 [PMID: 41278451 DOI: 10.4239/wjd.v16.i11.111366]

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