©The Author(s) 2025.
World J Diabetes. Nov 15, 2025; 16(11): 111223
Published online Nov 15, 2025. doi: 10.4239/wjd.v16.i11.111223
Published online Nov 15, 2025. doi: 10.4239/wjd.v16.i11.111223
Figure 7 Schematic representation of the role of ribonucleotide reductase regulatory subunit M2 in ferroptosis and diabetic nephropathy.
ROS: Reactive oxygen species; MDA: Malondialdehyde; SLC7A11: Solute carrier family 7 member 11; GPX4: Glutathione peroxidase 4; RRM2: Ribonucleotide reductase regulatory subunit M2; Scr: Serum creatinine; NGAL: Neutrophil gelatinase-associated lipocalin; KIM-1: Kidney injury molecule-1.
- Citation: Gao CC, Ding FF, Jiang X. RRM2 attenuates the renal tubular ferroptosis in diabetic kidney disease through PI3K/Akt/Nrf2 pathway. World J Diabetes 2025; 16(11): 111223
- URL: https://www.wjgnet.com/1948-9358/full/v16/i11/111223.htm
- DOI: https://dx.doi.org/10.4239/wjd.v16.i11.111223