RRM2 attenuates the renal tubular ferroptosis in diabetic kidney disease through PI3K/Akt/Nrf2 pathway

doi:10.4239/wjd.v16.i11.111223

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Nov 15, 2025; 16(11): 111223
Published online Nov 15, 2025. doi: 10.4239/wjd.v16.i11.111223

Table 4 Logistic multivariate regression for developing diabetic nephropathy

Characteristics	Odds ratio	95% confidence interval	P value
Duration (years)	1.854	1.191-2.884	0.006
SBP (mmHg)	1.091	1.026-1.160	0.005
eGFR (mL/min/1.73 m²)	0.946	0.909-0.986	0.008
Scr (μmol/L)	1.136	1.058-1.219	< 0.001
GSH (nmol/mL)	0.438	0.272-0.703	0.001
SLC7A11 (pg/mL)	0.953	0.911-0.998	0.041
GPX4 (ng/mL)	0.925	0.885-0.966	< 0.001
RRM2 (pg/mL)	0.820	0.712-0.945	0.006

SBP: Systolic blood pressure; eGFR: Estimated glomerular filtration rate; Scr: Serum creatinine; GSH: Glutathione; SLC7A11: Solute carrier family 7 member 11; GPX4: Glutathione peroxidase 4; RRM2: Ribonucleotide reductase regulatory subunit M2.

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Citation: Gao CC, Ding FF, Jiang X. RRM2 attenuates the renal tubular ferroptosis in diabetic kidney disease through PI3K/Akt/Nrf2 pathway. World J Diabetes 2025; 16(11): 111223
URL: https://www.wjgnet.com/1948-9358/full/v16/i11/111223.htm
DOI: https://dx.doi.org/10.4239/wjd.v16.i11.111223

Gao CC, Ding FF, Jiang X. RRM2 attenuates the renal tubular ferroptosis in diabetic kidney disease through PI3K/Akt/Nrf2 pathway. World J Diabetes 2025; 16(11): 111223 [PMID: 41278435 DOI: 10.4239/wjd.v16.i11.111223]

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