RRM2 attenuates the renal tubular ferroptosis in diabetic kidney disease through PI3K/Akt/Nrf2 pathway

Table 3 Correlation between serum ribonucleotide reductase regulatory subunit M2 and clinical indicators

Parameters	All subjects (n = 194)
	r value	P value
Age (years)	-0.147	0.041
BMI (kg/m2)	-0.126	0.080
Duration (years)	-0.390	< 0.001
SBP (mmHg)	-0.210	0.003
FBG (mmol/L)	-0.223	0.002
HbA1c (%)	-0.156	0.030
TG (mmol/L)	-0.022	0.763
TC (mmol/L)	-0.027	0.705
eGFR (mL/min/1.73 m2)	0.263	< 0.001
Scr (μmol/L)	-0.315	< 0.001
Urinary NGAL (ng/mL)	-0.153	0.034
Urinary KIM-1 (ng/mL)	-0.234	0.001
MDA (nmol/mL)	-0.326	< 0.001
GSH (nmol/mL)	0.275	< 0.001
SLC7A11 (pg/mL)	0.269	< 0.001
GPX4 (ng/mL)	0.305	< 0.001

The correlation between serum ribonucleotide reductase regulatory subunit M2 and other continuous variables, and was analyzed using the Pearson correlation test. BMI: Body mass index; SBP: Systolic blood pressure; FBG: Fasting blood glucose; HbA1c: Glycosylated hemoglobin; TG: Triglyceride; TC: Total cholesterol; eGFR: Estimated glomerular filtration rate; Scr: Serum creatinine; NGAL: Neutrophil gelatinase-associated lipocalin; KIM-1: Kidney injury molecule-1; MDA: Malondialdehyde; GSH: Glutathione; SLC7A11: Solute carrier family 7 member 11; GPX4: Glutathione peroxidase 4; RRM2: Ribonucleotide reductase regulatory subunit M2.