©The Author(s) 2025.
World J Diabetes. Nov 15, 2025; 16(11): 110428
Published online Nov 15, 2025. doi: 10.4239/wjd.v16.i11.110428
Published online Nov 15, 2025. doi: 10.4239/wjd.v16.i11.110428
Figure 1 Integrated epigenetic network in diabetic complications.
This schematic illustrates the interplay between major epigenetic modifications (DNA methylation, histone modifications, and non-coding RNAs) in driving chronic inflammation, oxidative stress, impaired neurovascular repair, and tissue degeneration. These processes contribute to the development and persistence of diabetic neuropathy (DN) and diabetic foot ulcers (DFUs) by disrupting key protective pathways and promoting pathological gene expression.
- Citation: Sanusi KO, Asiwe JN, Sulaimon FA, Bashar F, Yusuf SK, Abdulkadir HO. Diabetic neuropathy and wound healing: An update on epigenetic crosstalk. World J Diabetes 2025; 16(11): 110428
- URL: https://www.wjgnet.com/1948-9358/full/v16/i11/110428.htm
- DOI: https://dx.doi.org/10.4239/wjd.v16.i11.110428