Correlation of gut microbiota metabolite trimethylamine N-oxide with inflammatory levels and osteoporosis in patients with diabetic nephropathy

doi:10.4239/wjd.v16.i11.109919

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Nov 15, 2025; 16(11): 109919
Published online Nov 15, 2025. doi: 10.4239/wjd.v16.i11.109919

Table 3 Comparison of bone metabolism indexes between the two groups (mean ± SD)

	DN group (n = 115)	T2DM group (n = 115)	t	P value
PINP (μg/L)	43.13 ± 6.11	35.51 ± 4.87	10.461	0.000
β-CTX (ng/mL)	0.51 ± 0.11	0.43 ± 0.08	5.996	0.000
ALP (U/L)	69.16 ± 7.12	65.61 ± 7.09	3.788	0.000
Lumbar spine BMD (g/cm²)	0.77 ± 0.14	0.81 ± 0.14	-2.552	0.011
Hip BMD (g/cm²)	0.66 ± 0.11	0.71 ± 0.12	-3.624	0.000

BMD: Bone mineral density; PINP: Procollagen type I N-terminal propeptide; β-CTX: Β-CrossLaps; ALP: Alkaline phosphatase; T2DM: Type 2 diabetes mellitus; DN: Diabetic nephropathy.

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Citation: Pan ZL, Li MQ, Zhang J, Xue LY, Shi YP. Correlation of gut microbiota metabolite trimethylamine N-oxide with inflammatory levels and osteoporosis in patients with diabetic nephropathy. World J Diabetes 2025; 16(11): 109919
URL: https://www.wjgnet.com/1948-9358/full/v16/i11/109919.htm
DOI: https://dx.doi.org/10.4239/wjd.v16.i11.109919

Pan ZL, Li MQ, Zhang J, Xue LY, Shi YP. Correlation of gut microbiota metabolite trimethylamine N-oxide with inflammatory levels and osteoporosis in patients with diabetic nephropathy. World J Diabetes 2025; 16(11): 109919 [PMID: 41278450 DOI: 10.4239/wjd.v16.i11.109919]

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