Correlation of gut microbiota metabolite trimethylamine N-oxide with inflammatory levels and osteoporosis in patients with diabetic nephropathy

Table 2 Comparison of inflammatory indicators and trimethylamine N-oxide between the two groups of patients (mean ± SD)

	DN group (n = 115)	T2DM group (n = 115)	t	P value
CRP (mg/L)	12.16 ± 5.44	6.95 ± 1.77	5.760	0.000
IL-6 (ng/L)	331.14 ± 72.13	245.57 ± 42.04	9.749	0.000
IL-8 (ng/L)	345.04 ± 86.16	314.12 ± 75.13	10.659	0.000
TNF-α (ng/L)	11.28 ± 4.55	7.15 ± 1.80	2.972	0.003
TMAO (ng/mL)	123.47 ± 22.65	108.06 ± 17.62	9.041	0.000

T2DM: Type 2 diabetes mellitus; DN: Diabetic nephropathy; TMAO: Trimethylamine N-oxide; CRP: C-reactive protein; IL-6: Interleukin-6; IL-8: Interleukin-8; TNF-α: Tumor necrosis factor.