Association between Zhejiang University index and metabolic dysfunction-associated steatotic liver disease in patients with type 2 diabetes mellitus

doi:10.4239/wjd.v16.i10.110406

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Oct 15, 2025; 16(10): 110406
Published online Oct 15, 2025. doi: 10.4239/wjd.v16.i10.110406

Table 4 Comparison of baseline clinical characteristics in type 2 diabetes mellitus patients grouped according to Zhejiang University index, mean ± SD/n (%)

Variables	Low ZJU (n = 343)	High ZJU (n = 345)	P value
Age (years)	59.99 ± 10.71	53.44 ± 13.72	< 0.001
BMI (kg/m²)	23.29 ± 2.48	27.02 ± 3.66	< 0.001
SBP (mmHg)	127.95 ± 18.00	130.80 ± 18.13	0.039
DBP (mmHg)	75.46 ± 10.73	81.26 ± 11.64	< 0.001
HbA1c (%)	8.41 ± 2.08	9.78 ± 2.29	< 0.001
WBC (× 10⁹/L)	6.14 ± 1.59	6.57 ± 1.79	< 0.001
RBC (× 10¹²/L)	4.91 ± 7.70	5.01 ± 6.57	0.864
PLT (× 10⁹/L)	185.45 ± 57.16	195.39 ± 55.44	0.021
TP (g/L)	63.83 ± 5.33	66.62 ± 5.56	< 0.001
ALT (U/L)	21.01 ± 14.64	37.10 ± 38.29	< 0.001
AST (U/L)	22.46 ± 24.97	27.51 ± 22.44	0.005
BUN (mmol/L)	6.84 ± 2.17	6.53 ± 2.51	0.078
Scr (mmol/L)	67.52 ± 36.89	67.74 ± 48.46	0.947
UA (mmol/L)	317.97 ± 83.05	353.39 ± 104.97	< 0.001
TC (mmol/L)	4.30 ± 1.09	5.13 ± 1.61	< 0.001
TG (mmol/L)	1.40 ± 0.97	3.25 ± 3.41	< 0.001
HDL-C (mmol/L)	1.12 ± 0.27	1.08 ± 0.35	0.04
LDL-C (mmol/L)	2.60 ± 0.84	3.04 ± 0.96	< 0.001
FBG (mmol/L)	6.56 ± 1.95	10.44 ± 4.31	< 0.001
Sex (male)	240 (69.97)	218 (63.19)	0.059
Smoking	120 (34.99)	134 (38.84)	0.295
Drinking	116 (33.82)	156 (45.22)	0.002
Hypertension	182 (53.06)	178 (51.59)	0.7
CAD	49 (14.29)	22 (6.38)	< 0.001
MASLD	123 (35.86)	220 (63.77)	< 0.001

BMI: Body mass index; SBP: Systolic blood pressure; DBP: Diastolic blood pressure; HbA1c: Glycated hemoglobin; WBC: White blood cell count; RBC: Red blood cell count; PLT: Platelet count; TP: Total protein; ALT: Alanine aminotransferase; AST: Aspartate transaminase; BUN: Blood urea nitrogen; Scr: Serum creatinine; UA: Uric acid; TC: Total cholesterol; TG: Triglyceride; HDL-C: High-density lipoprotein cholesterol; LDL-C: Low-density lipoprotein cholesterol; FBG: Fasting blood glucose; CAD: Coronary artery disease; ZJU: Zhejiang University; MASLD: Metabolic dysfunction-associated steatotic liver disease.

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Citation: Tao XY, Pan TR, Zhong X, Pan XY. Association between Zhejiang University index and metabolic dysfunction-associated steatotic liver disease in patients with type 2 diabetes mellitus. World J Diabetes 2025; 16(10): 110406
URL: https://www.wjgnet.com/1948-9358/full/v16/i10/110406.htm
DOI: https://dx.doi.org/10.4239/wjd.v16.i10.110406

Tao XY, Pan TR, Zhong X, Pan XY. Association between Zhejiang University index and metabolic dysfunction-associated steatotic liver disease in patients with type 2 diabetes mellitus. World J Diabetes 2025; 16(10): 110406 [PMID: 41113492 DOI: 10.4239/wjd.v16.i10.110406]

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