Polygenic risk score for predicting diabetic retinopathy in patients with type 2 diabetes: A twenty-year follow-up study

Figure 2 Kaplan-Meier curves depicting the probability over time in the bottom 25% (blue) and top 10% (green) groups of polygenic risk score. A: Patients with type 2 diabetes remaining diabetic retinopathy (DR)-free; B: Patients with DR not requiring more than four laser treatments; C: Patients with DR not requiring vitreoretinal surgery. Hazard ratios for patients in the top 10% of polygenic risk score were estimated using a Cox regression model adjusted for diagnosis age and glycated hemoglobin A1c. T2D: Type 2 diabetes; DR: Diabetic retinopathy; PRS: Polygenic risk score; HR: Hazard ratio; CI: Confidence interval; HbA1c: Glycated hemoglobin A1c.