Polygenic risk score for predicting diabetic retinopathy in patients with type 2 diabetes: A twenty-year follow-up study

doi:10.4239/wjd.v16.i10.110138

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Diabetes. Oct 15, 2025; 16(10): 110138
Published online Oct 15, 2025. doi: 10.4239/wjd.v16.i10.110138

Table 2 The ten most significantly affected biological pathways and molecules related to diabetic retinopathy identified through ingenuity pathway analysis

Ingenuity canonical pathways	-log (P value)	Molecules
Assembly of RNA polymerase I complex	2.57	TAF1C
Rap1 signalling	2.48	PRKG1
BMAL1: CLOCK, NPAS2 activates circadian gene expression	2.26	KLF15
SIRT1 negatively regulates rRNA expression	2.22	TAF1C
Oxytocin in spinal neurons signaling pathway	2.14	PRKG1
Netrin-1 signaling	1.99	SLIT3
RNA polymerase I transcription	1.99	TAF1C
B-WICH complex positively regulates rRNA expression	1.97	TAF1C
Platelet homeostasis	1.75	PRKG1
Beta-catenin independent Wnt signaling	1.68	PRKG1

Rap1: Ras-associated protein 1; BMAL1: Brain and muscle ARNT-like 1; NPAS2: Neuronal PAS domain protein 2; SIRT1: Silent information regulator sirtuin 1; TAF1C: TATA-box binding protein associated factor, RNA polymerase I subunit C; PRKG1: CGMP-dependent protein kinase 1; KLF15: Kruppel-like factor 15; SLIT3: Slit guidance ligand 3.

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Citation: Huang YC, Liao WL, Lin HJ, Huang YT, Chang YW, Yang JS, Weng AL, Tsai FJ. Polygenic risk score for predicting diabetic retinopathy in patients with type 2 diabetes: A twenty-year follow-up study. World J Diabetes 2025; 16(10): 110138
URL: https://www.wjgnet.com/1948-9358/full/v16/i10/110138.htm
DOI: https://dx.doi.org/10.4239/wjd.v16.i10.110138

Huang YC, Liao WL, Lin HJ, Huang YT, Chang YW, Yang JS, Weng AL, Tsai FJ. Polygenic risk score for predicting diabetic retinopathy in patients with type 2 diabetes: A twenty-year follow-up study. World J Diabetes 2025; 16(10): 110138 [PMID: 41113490 DOI: 10.4239/wjd.v16.i10.110138]

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