Exosomal transfer of miR-375-3p from pancreatic β cells to hepatocytes impairs hepatic glycogenesis via Rbpj repression

Figure 7 Schematic diagram of the mechanism underlying pancreatic-cell-derived miR-375-3p inducing impairment of hepatocyte glycogenesis. Glucotoxicity specifically upregulates miR-375-3p in pancreatic cells but not in hepatocytes. Pancreatic cell-derived miR-375-3p is delivered to hepatocytes via exosomes, leading to reduced glycogenesis. miR-375-3p inhibits the AKT/GSK signaling pathway by targeting Rbpj, thereby impairing hepatocyte glycogenesis. Figure created by Figdraw.