Exosomes from adipose-derived stem cells: A potential therapeutic strategy for diabetic foot ulcers

Table 1 The cargo RNAs and functions of exosomes from adipose-derived stem cells in promoting diabetic wound healing[60,63,68,70,72,79,90,100,101]

Cargo	Target	Experimental model	Concentration	Function	Ref.
circRps5	miR-124-3p	C57BL/6 mice (8 weeks old, male)	2 mg/100 μL PBS	Promote M2 macrophages polarization	Yin and Shen[60]
circ-Snhg11	miR-144-3p	C57BL/6 mice	100 μL PBS containing 200 μg ADSC-exosomes	Promote M2 macrophages polarization	Shi et al[63]
mmu_circ_0001052	miR-106a-5p	BALB/c mice (5 weeks old, male)	20 μg/mL	Promote angiogenesis	Liang et al[68]
miR-146a-5p	JAZF1	HUVEC and C57/BL mice (8 weeks old, male)	50, 100 and 200 μg/mL	Promote angiogenesis	Che et al[70]
circ-0001747	miR-199a-5p	BALB/C mice	Not clear	Promote wound healing and accelerate vascular regeneration	Wang et al[72]
miRNA-21-5p	HaCaT	HaCa and Sprague-Dawley rats (5 weeks old, male)	Not clear	Promote the proliferation and migration of keratinocytes	Lv et al[79]
miR-130b-5p	TGFBR3	C57BL/6 mice (8 weeks old, male)	1 μg/μL in 100 μL PBS	Promote collagen formation and angiogenesis, and activate the functions of fibroblasts and vascular endothelial cells	Yu et al[90]
miR-125a-3p	PTEN	HUVEC and C57BL/6 mice (6-8 weeks old)	25 μg and 50 μg/mL	Promote the proliferation, migration, and angiogenesis of human umbilical vein endothelial cells	Pi et al[100]
lncRNA H19	miR-19b	BALB/c mice (4 weeks old, male)	Exosomes isolated from 1 × 106 ADSCs suspended in 200 μL PBS	Promote the proliferation, migration, and invasion of HSF cells	Qian et al[101]

lncRNA: Long noncoding RNA; JAZF1: Juxtaposed with another zinc finger gene 1; HaCaT: Human keratinocyte cell line; HUVEC: Human umbilical vein endothelial cells; PBS: Phosphate-buffered saline; ADSC: Adipose-derived stem cells; HSF: Human skin fibroblast.