Right ventricular dysfunctions in type 1 diabetic mice: A longitudinal study

Figure 5 The impact of type 1 diabetes on cardiac fibrosis in the left ventricle of diabetic OVE26 mice. A-D: Changes in fibronectin and connective tissue growth factor protein levels in the left ventricle of 12-week-old mice were assayed by Western blot; E-G: Changes of left ventricle mRNA expression of fibronectin, connective tissue growth factor, and type I collagen were measured by quantitative reverse transcription polymerase chain reaction. Data are presented as mean ± SD (n = 3-4). ^aP < 0.05 vs control FVB mice; ^bP < 0.01 vs control FVB mice; ^cP = 0.06 vs control FVB mice. FN: Fibronectin; CTGF: Connective tissue growth factor; LV: Left ventricle; Col I: Type I collagen.