Long-term effects of gestational diabetes mellitus on the pancreas of female mouse offspring

Figure 4 Adult female offspring born from dams with streptozotocin-induced gestational diabetes mellitus have an increased number of macrophages in the pancreatic acinar cells, but not in the pancreatic islets. A, B, D, and E: Representative confocal images of pancreatic cells expressing CD68 (cluster of differentiation 68) for macrophage staining in acinar pancreatic tissue or pancreatic islets from offspring born of vehicle or streptozotocin (STZ) injected dams (40 μm-thick); C and F: Significantly greater number of macrophages were found in the acinar pancreatic tissue, but not in the pancreatic islets of offspring born from dams treated with STZ compared to control mice. ^aP < 0.05 Student t test, n = 4-5 per group. Data are shown as mean ± SEM. CD68: Cluster of differentiation 68; VEH: Vehicle; STZ: Streptozotocin.