Potential application of Nardostachyos Radix et Rhizoma-Rhubarb for the treatment of diabetic kidney disease based on network pharmacology and cell culture experimental verification

Figure 2 Identification of drug and disease targets and protein-protein interaction enrichment analysis. A: Drug and disease targets; B: Intersection of drug and disease targets; C: Drug-disease-target network diagram; D: Protein-protein interaction (PPI) network diagram of intersection genes of Nardostachyos Radix et Rhizoma-rhubarb drug pair (NRDP) and disease; E: PPI network containing 73 intersection targets and 10 core targets constructed using Cytoscape; F: Selected core targets and active components of NRDP were analyzed. Each node’s color denotes the degree.