Assessment of pathogenicity and functional characterization of APPL1 gene mutations in diabetic patients

doi:10.4239/wjd.v15.i2.275

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Feb 15, 2024; 15(2): 275-286
Published online Feb 15, 2024. doi: 10.4239/wjd.v15.i2.275

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Figure 6 Role of adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 in the insulin pathway. AKT: Serine/threonine kinase Akt; APPL1: Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1; AS160: Akt substrate of 160 kDa; GLUT4: Glucose transporter type 4; IRS1/2: Insulin receptor substrate 1/2; PDK1: Pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1; PI3K: Phosphatidylinositol 3 - kinase; PIP3: Phosphatidylinositol-3,4,5-trisphosphate; TRB3: Tribble homolog 3.

Citation: Shi P, Tian Y, Xu F, Liu LN, Wu WH, Shi YZ, Dai AQ, Fang HY, Li KX, Xu C. Assessment of pathogenicity and functional characterization of APPL1 gene mutations in diabetic patients. World J Diabetes 2024; 15(2): 275-286
URL: https://www.wjgnet.com/1948-9358/full/v15/i2/275.htm
DOI: https://dx.doi.org/10.4239/wjd.v15.i2.275