Role of insulin in pancreatic microcirculatory oxygen profile and bioenergetics

Figure 5  Metabolic characteristics of the islet microvascular endothelial cells. A-E: Oxygen consumption rates associated with mitochondrial ATP production, proton leak, coupling efficiency, non-mitochondrial respiration and oxidative metabolism; F: Endothelial glycolytic capacity evaluated by extracellular acidification rate; The data are presented as the mean ± SEM, n = 4 for each group. ^aP < 0.05, ^bP < 0.01 vs Control; G: The correlation analysis among pancreatic microcirculatory oxygen profile and microvascular endothelial mitochondrial metabolism. The correlation coefficients (r) in the control, glucotoxicity-exposed, and insulin-treated groups are illustrated as matrix plots. The numbers in the figure represent the correlation coefficient (r) values. SO₂: oxygen saturation; rHb, relative amount of hemoglobin; PO₂: partial oxygen pressure. OCR: Oxygen consumption rate; HG: High glucose; Ins: Insulin.