Role of insulin in pancreatic microcirculatory oxygen profile and bioenergetics

Figure 4  Basal respiration and glycolytic activity in islet microvascular endothelial cells. The oxygen consumption rate and extracellular acidification rate were measured and compared among control, glucotoxicity-exposed islet microvascular endothelial cells (IMECs) (HG), and IMECs (HG + Ins). A: Basal respiration among groups; B: Basal glycolytic activity among groups; C: Glucotoxicity-exposed and insulin administered IMECs display distinct metabolic phenotypes. The data are presented as the mean ± SEM, n = 4 for each group. ^aP < 0.05. OCR: Oxygen consumption rate; ECAR: Extracellular acidification rate; HG: High glucose; Ins: Insulin.