Clopidogrel delays and can reverse diabetic nephropathy pathogenesis in type 2 diabetic db/db mice

Figure 2 Clopidogrel improves the kidney function of db/db mice. Data are shown as mean ± SD values of n = 6 mice per group. ^aP < 0.05 vs wild type mice; ^bP < 0.05 vs db/db mice. A: Urinary albumin/creatinine ratio. Mice at 12 wk of age were defined as the baseline; B: Periodic acid-Schiff staining of kidney sections for glycogen content and Masson’s trichrome staining for collagenous connective tissue fibers. Magnification: × 400. WT: Wild type; db/db: db/db mice; Clo: Clopidogrel; Clo (L, M, H): Clopidogrel at 5, 10, or 20 mg/kg, respectively.