Immediate-release tofacitinib reduces insulin resistance in non-diabetic active rheumatoid arthritis patients: A single-center retrospective study

Figure 1 Characteristics of homeostatic model assessment-insulin resistance levels in active rheumatoid arthritis patients naïve to biologic synthetic disease-modifying anti-rheumatic drugs. A: Positive correlation between 28-joint disease activity score 28 values and homeostatic model assessment (HOMA)-insulin resistance (IR) levels (P = 0.039) before tofacitinib (TOF) therapy; B: Serial calculations of HOMA-IR levels in 3 patients with high baseline IR at weeks 0, 4, 8, 12 and 24 after TOF therapy. There were significantly lower levels at week 24 as compared with those at week 0 (P < 0.01). HOMA-TR: Homeostatic model assessment-insulin resistance.