Cognitive disorder and dementia in type 2 diabetes mellitus

Figure 3 Tau protein regulation. A: Insulin and Tau protein with no insulin increase hyperphosphorylate of Tau folding the protein; B: O-GlcNAcylation and Tau protein can regulate glucose amination to serine and threonine decrease the formation of Tau folding. Some pictures were taken from Qiagen Pathways. GSK3: Glycogen synthase kinase-3; IGF-1: Insulin-like growth factor 1; Pi3K: Phosphoinositide-3 kinase; Akt: Serine/threonine specific protein kinase; GlcNAc: O-GlcNAcylation.