Non-coding RNAs: Role in diabetic foot and wound healing

Figure 1 A diagram of the diabetic foot wound healing process. In the inflammation phase, macrophages produce pro-inflammatory cytokines. In the proliferation phase, angiogenic growth factors promote angiogenesis by stimulating endothelial cell proliferation and migration. In the regeneration phase, fibroblasts proliferate and secrete extracellular matrix components to provide supportive structures for cell proliferation and migration to restore skin tissue function. Mφ: Macrophages; VEGF: Vascular endothelial growth factor; EGF: Epidermal growth factor; HIF-1α: Hypoxia-inducible factor 1 α; ECM: Extracellular matrix.