Non-coding RNAs: Role in diabetic foot and wound healing

Table 4 Non-coding RNAs in cell therapy

Name	Origin	Expression	Sponge	Target gene	Phase	Ref.
miRNA-155	MSC	Up	/	FGF7	Proliferation	Moura et al[36], 2019; Gondaliya et al[51], 2022
miR-129	MSC	Down	/	TRAF6	Proliferation	Hu et al[92], 2022
miRNA-221-3p	EPC	Down	/	HIPK2	Proliferation	Yu et al[94], 2022
LncRNA H19	MSC	Up	miRNA-152-3P	PTEN	Proliferation	Li et al[95], 2020
MALAT1	MSC	Down	miR-205-5p	VEGF	Proliferation	Zhu et al[97], 2019
Lnc KLF3-AS1	BMSC	Down	miR-383	VEGFA	Proliferation	Han et al[99], 2022
Circ_0000250	ADSC	Down	miR-128-3p	SIRT1	Proliferation	Shi et al[100], 2020
Circ_ARHGAP12	MSC	Down	miR-301b-3p	ATG16L1, ULK2	Proliferation	Meng et al[101], 2022
Circ HIPK3	MSC	Down	miR-20b-3p	Nrf2/VEGFA	Proliferation	Liang et al[102], 2022

MSC: Mesenchymal stem cells; FGF7: Fibroblast growth factor 7; TRAF6: Tumor necrosis factor receptor-associated factor 6; EPC: Epithelial progenitor cells; HIPK2: Homeodomain-interacting protein kinase 2; PTEN: Phosphatase and tensin homolog; SIRT1: Sirtuin 1; VEGF: Vascular endothelial growth factor; Lnc KLF3-AS1: LncRNA Kruppel-like factor 3 antisense RNA 1; BMSC: Bone marrow mesenchymal cells; ADSC: Adipose-derived stem cells; Circ HIPK3: Circular RNA homeodomain-interacting protein kinase three; Nrf2: Nuclear factor erythroid 2-related factor 2; MALAT1: Metastasis-associated lung adenocarcinoma transcript 1; Lnc: Long non-coding; miRNA: Micro RNA.