Review
Copyright ©The Author(s) 2022.
World J Diabetes. Dec 15, 2022; 13(12): 1001-1013
Published online Dec 15, 2022. doi: 10.4239/wjd.v13.i12.1001
Table 2 Long non-coding RNAs in diabetic foot and wound healing
Name
Expression
Sponge
Animal
Target gene
Pathway
Phase
Ref.
GAS5Up/MouseSTAT1/InflammationHu et al[64], 2020
/MouseTAF15HIF-1α/VEGFProliferationPeng et al[65], 2021
MALAT1Down//HIF-1α/Nrf2ProliferationJayasuriya et al[69], 2020
Lnc01435Up/MouseYY1, HDACsNotchProliferationFu et al[70], 2022
H19UpmiRNA-29bMouseFBN1TGF-β/SmadRegenerationLi et al[72], 2021
Up/RatCTGF, SRFMAPKRegenerationLi et al[74], 2020
URIDSUp/RatPlod1VEGF/TGF-βRegenerationHu et al[27], 2020
CASC2DownmiR-155MouseHIF-1α/RegenerationHe et al[76], 2022
GAS5: Growth arrest specific 5; STAT1: Signal transducer and activator of transcription 1; TAF15: TATA box-binding protein associated factor 15; MALAT1: Metastasis-associated lung adenocarcinoma transcript 1; YY1: Yin yang 1; HDAC8: Histone deacetylase 8; FBN1: Fibrillin 1; CTGF: Connective tissue growth factor; SRF: Serum response factor; URIDS: Upregulated in diabetic skin; Plod1: Procollagen-lysine and 2-oxoglutarate 5-dioxygenase 1; CASC2: Cancer susceptibility candidate 2; HIF-1α: Hypoxia-inducible factor 1 α; VEGF: Vascular endothelial growth factor; TGF: Transforming growth factor; Nrf2: Nuclear factor erythroid 2-related factor 2.