Growing importance of urogenital candidiasis in individuals with diabetes: A narrative review

Table 2 Biofilm production process

Phase	Phase name	Description
1	Adherence	In the first 3 h, individual C. albicans cells adhere to the substrate, which forms the basal layer of the biofilm
2	Intermediate phase	In 11-14 h, biofilm is shaped during this phase of cell proliferation and filamentation, in which the formation of hyphae occurs, marking the beginning of true biofilm formation
3	Maturation phase	In 20-48 h, there is a complete penetration of all layers of cells attached to the surface; extracellular polysaccharide matrix accumulates at this stage of maturation
4	Dispersion	After 24 h, the final phase involves separation of non-adherent cells from the biofilm, resulting in possible development of new biofilms and dissemination in the tissue

C. albicans: Candida albicans.