Genetics of macrovascular complications in type 2 diabetes

Table 1 Genetic variants associated with macrovascular complications of type 2 diabetes mellitus

	Gene symbol	Region	dbSNP ID	Risk allele	Condition	Ref.
1	GLUL	1q25	rs10911021	C	CAD	Qi et al[18], Beaney et al[19], and Look AHEAD Research Group[20]
2	MGMT	10q26.3	rs9299870	A	Cardiovascular mortality	Shah et al[23]
3	Intergenic	5q13	rs57922	T	Cardiovascular mortality	Shah et al[23]
4	CDKN2B-AS1	9p21	rs10757274	G	MI	Doria et al[11], and Zhang et al[17]
5	CDKN2B-AS1	9p21	rs2383206	G	MI	Doria et al[11], and Zhang et al[17]
6	CDKN2B-AS1	9p21	rs4977574	G	CAD	Qi et al[12]
7	PHACTR1	6p24	rs12526453	C	CAD	Qi et al[12]
8	CELSR2	1p21	rs646776	T	CAD	Qi et al[12]
9	HNF1A	12q24	rs2259816	T	CAD	Qi et al[12]
10	PCSK9	1p32	rs11206510	T	CAD	Qi et al[12]
11	LPA	6q25	rs74617384	T	CAD	Fall et al[24]
12	CDKN2B-AS1	9p21	rs10811652	C	CAD	Fall et al[24]

CAD: Coronary artery disease; MI: Myocardial infarction.