Exercise intervention under hypoxic condition as a new therapeutic paradigm for type 2 diabetes mellitus: A narrative review

Figure 2 Environment control chamber. Various technical equipment has been developed to create hypoxic conditions. Artificially produced hypoxia can be obtained by changing barometric pressure (hypobaric hypoxia) or by changing the fraction of oxygen (FiO₂) (normobaric hypoxia). The FiO₂ is always constant at sea level (FiO₂ ca. 21%), and the barometric pressure decreases with higher altitude. The hypoxic conditions can be created using a special chamber at rest or during exercise.