Elevated retinol binding protein 4 levels are associated with atherosclerosis in diabetic rats via JAK2/STAT3 signaling pathway

doi:10.4239/wjd.v12.i4.466

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Apr 15, 2021 (publication date) through Apr 26, 2024

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

World J Diabetes. Apr 15, 2021; 12(4): 466-479
Published online Apr 15, 2021. doi: 10.4239/wjd.v12.i4.466

Table 2 Comparison of indicators among each group

Index	Group NC (n = 20)	Group DM (n = 25)	Group DA (n = 25)	F	P value
Weight (kg)	491.84 ± 80.82	504.61 ± 63.16	526.07 ± 85.66	1.155	0.321
TG (mmol/L)	0.65 ± 0.10	1.36 ± 0.17^a	1.82 ± 0.28^a^,^b	191.339	< 0.001
LDL-c (mmol/L)	0.35 ± 0.12	0.49 ± 0.12^a	0.57 ± 0.14^a^,^b	17.562	< 0.001
HDL-c (mmol/L)	1.07 ± 0.19	0.98 ± 0.20	0.71 ± 0.11^a^,^b	27.856	< 0.001
TC (mmol/L)	1.98 ± 0.39	2.23 ± 0.42	2.95 ± 0.50^a^,^b	30.234	< 0.001
FPG (mmol/L)	5.42 ± 0.82	13.37 ± 2.16^a	14.04 ± 2.40^a	125.463	< 0.001
FINS (mU/L)	9.84 ± 1.99	14.42 ± 2.12^a	19.24 ± 3.17^a^,^b	77.990	< 0.001
HbA1C (%)	5.10 ± 0.81	9.95 ± 2.02^a	10.86 ± 1.65^a	78.800	< 0.001
RBP4 (ng/mL)	15.37 ± 2.07	21.23 ± 2.70^a	32.28 ± 4.68^a^,^b	144.583	< 0.001
AI	0.58 ± 0.23	1.71 ± 0.71^a	3.31 ± 0.76^a^,^b	105.551	< 0.001
HOMA-IR	2.38 ± 0.62	8.49 ± 1.36^a	12.24 ± 2.82^a^,^b	149.994	< 0.001

^aP < 0.05 vs control group.

^bP < 0.05 vs diabetic rat group. NC: Control group; DM: Diabetic rat group; DA: Diabetic atherosclerotic rat group; TG: Triglycerides; LDL-c: Low-density lipoprotein cholesterol; HDL-c: High-density lipoprotein cholesterol; TC: Total cholesterol; FPG: Fasting plasma glucose; FINS: Fasting insulin; HbA1C: Hemoglobin A1c; RBP4: Retinol binding protein 4; AI: Atherogenic indexes; HOMA-IR: Homeostasis model assessment of insulin resistance.

Citation: Zhou W, Ye SD, Wang W. Elevated retinol binding protein 4 levels are associated with atherosclerosis in diabetic rats via JAK2/STAT3 signaling pathway. World J Diabetes 2021; 12(4): 466-479
URL: https://www.wjgnet.com/1948-9358/full/v12/i4/466.htm
DOI: https://dx.doi.org/10.4239/wjd.v12.i4.466